Endocrine Mechanisms in PCOS: A Synthesis of Current Research
Main Article Content
Abstract
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine condition that affects women of reproductive age. This study reviews the endocrine mechanisms underlying PCOS and their relationship with insulin resistance, and explores the relationship between endocrine mechanisms and insulin resistance in PCOS. The sample consisted of a bibliographic review of original scientific studies and systematic reviews related to the topic, using electronic databases and bibliographic management tools such as PubMed and Mendeley. The results show a close association between hyperandrogenism, insulin resistance and ovarian dysfunction in PCOS, highlighting the importance of addressing these conditions comprehensively in the clinical management of the disease. The findings suggest the need to reduce androgen levels to optimize clinical outcomes in women with PCOS. The discussion emphasizes the importance of considering insulin resistance as a central component in the pathophysiology of PCOS and highlights the need for future research to develop more effective and personalized therapeutic approaches.
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How to Cite
Endocrine Mechanisms in PCOS: A Synthesis of Current Research. (2024). Revista Repique, 6(1), 95-116. https://doi.org/10.31876/repique.v6i1.252
References
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Bellver, J., Rodríguez-Tabernero, L., Robles, A., Muñoz, E., Martínez, F., Landeras, J., García-Velasco, J., Fontes, J., Álvarez, M., Álvarez, C., & Acevedo, B. (2018). Polycystic ovary syndrome throughout a woman’s life. Journal of Assisted Reproduction and Genetics, 35(1), 25–39. https://doi.org/10.1007/s10815-017-1047-7
Can, M., Duran, C., Guney, I., Elmas, H., Ayhan, M., & Erdem, S. S. (2020). The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome. Clinica e Investigacion En Arteriosclerosis : Publicacion Oficial de La Sociedad Espanola de Arteriosclerosis, 32(6), 256–262. https://doi.org/10.1016/J.ARTERI.2020.04.003
Dapas, M., & Dunaif, A. (2022). Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification. Endocrine Reviews, 43(6), 927–965. https://doi.org/10.1210/endrev/bnac001
Ding, H., Zhang, J., Zhang, F., Zhang, S., Chen, X., Liang, W., & Xie, Q. (2021). Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome. Frontiers in Endocrinology, 12. https://doi.org/10.3389/FENDO.2021.741764
Girón Salazar, A. G. (2022). Diagnóstico y tratamiento del síndrome de ovario poliquístico e infertilidad. Revista Diversidad Científica, 2(2), 85–93. https://doi.org/10.36314/DIVERSIDAD.V2I2.41
Invernizzi, P., Crisosto, N., Ladrón De Guevara, A., Maliqueo, M., Varela, N., & Echiburú, B. (2022). Respuesta a metformina en el síndrome de Ovario Poliquístico (SOP): Rol de las variantes genéticas. Rev Chil Endo Diab, 15(2), 63–70.
Kriebel Haehner, M., Morún Calvo, D., Rodriguez Alfaro, A., Zuñiga Villegas, A., General, M., José, S., & Rica, C. (2021). Síndrome de Ovario Poliquístico. Revista Ciencia y Salud Integrando Conocimientos, 5(2), ág.71-81. https://doi.org/10.34192/CIENCIAYSALUD.V5I2.275
Luiza, M., Alves, S., Ditzel, R., Donne, D., Romano, R. M., & Romano, M. A. (2022). Polycystic ovary syndrome (PCOS), pathophysiology and treatment, a review. Research, Society and Development, 11(9), e25111932469–e25111932469. https://doi.org/10.33448/RSD-V11I9.32469
Rojas, M., & Fernández, K. (2018). Síndrome de Ovarios Poliquísticos Polycystic Ovary Syndrome. Medicina Legal de Costa Rica Edición Virtual, 35(1).
Ortiz-Flores, A. E., Luque-Ramírez, M., & Escobar-Morreale, H. F. (2019). Síndrome de ovario poliquístico en la mujer adulta. Medicina Clínica, 152(11), 450–457. https://doi.org/10.1016/J.MEDCLI.2018.11.019
Ruiz-García, A. (2022). [Beating polycystic ovarian syndrome with lifestyle interventions]. Semergen, 48(3), 151–153. https://doi.org/10.1016/J.SEMERG.2022.01.003
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022a). Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/IJMS23020583
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022b). Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/IJMS23020583
Szukiewicz, D., Trojanowski, S., Kociszewska, A., & Szewczyk, G. (2022). Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors. International Journal of Molecular Sciences, 23(23). https://doi.org/10.3390/IJMS232314663
Tabares, R. G., León, A. D., Galindo, L. T., González, A. S., Linares, L. G., & González, F. A. A. (2018). Hiperandrogenismo y trastornos metabólicos en mujeres con síndrome de ovario poliquístico. Revista Cubana de Endocrinología, 29(3), 1–11. http://scielo.sld.cu
Ventura-Arizmendi, E., Hernández-Valencia, M., Ventura-Arizmendi, E., & Hernández-Valencia, M. (2019). La esteroidogénesis en el síndrome de ovarios poliquísticos. Gaceta Médica de México, 155(2), 184–190. https://doi.org/10.24875/GMM.18003955